Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 9/20 | 0.60 |
| ▸ | CDK2 | P24941 | 12/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 11/20 | 0.53 |
| ▸ | JUN | P05412 | 10/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.53 |
| ▸ | CDK9 | P50750 | 4/20 | 0.53 |
| ▸ | CCNH | P51946 | 4/20 | 0.53 |
| ▸ | CCNK | O75909 | 3/20 | 0.53 |
| ▸ | CDK13 | Q14004 | 3/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20412369 | 1.00 | CDK7 (0.60) | CDK7CDK2MAPK8MAPK9JUN | |
| SCHEMBL17150751 | 1.00 | CDK7 (0.60) | CDK7CDK2MAPK8MAPK9JUN | |
| SCHEMBL16655229 | 0.92 | CDK7 (0.63) | CDK7CDK2MAPK8MAPK9JUN | |
| SCHEMBL17151972 | 0.92 | CDK7 (0.54) | CDK7CDK2MAPK8MAPK9JUN | |
| SCHEMBL17150432 | 0.90 | CDK7 (0.51) | CDK7CDK2MAPK8MAPK9JUN | |
| SCHEMBL19024433 | 0.90 | CDK7 (0.65) | CDK7CDK2MAPK8MAPK9JUN | |
| SCHEMBL17151935 | 0.86 | CDK7 (0.58) | CDK7CDK2MAPK8MAPK9JUN | |
| SCHEMBL17150692 | 0.86 | CDK7 (0.70) | CDK7CDK2CCNT1CDK9CCNH | |
| SCHEMBL20412368 | 0.86 | CDK7 (0.70) | CDK7CDK2CCNT1CDK9CCNH | |
| SCHEMBL17150704 | 0.86 | CDK7 (0.62) | CDK7CDK2MAPK8MAPK9JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489232-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |
| WO-2015154039-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | WO | disclosed |
| WO-2015154038-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | WO | disclosed |