Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 11/20 | 0.38 |
| ▸ | BRAF | P15056 | 11/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714733 | 0.91 | PIK3C3 (0.46) | KITBRAFPIK3C3GSK3AGSK3B | |
| SCHEMBL1716091 | 0.89 | KIT (0.38) | HDAC1HDAC3HDAC2KITBRAF | |
| SCHEMBL1715787 | 0.85 | TP53 (0.43) | KITBRAF | |
| SCHEMBL1715737 | 0.84 | MAPK8 (0.45) | KITBRAFPIK3C3GSK3AGSK3B | |
| SCHEMBL1714811 | 0.84 | KIT (0.42) | KITBRAFAURKAAURKB | |
| SCHEMBL1715900 | 0.84 | AURKA (0.47) | HDAC1KITBRAFAURKA | |
| SCHEMBL1716023 | 0.83 | KIT (0.53) | KITBRAFAURKAAURKB | |
| SCHEMBL1714728 | 0.83 | KIT (0.44) | KITBRAFAURKAAURKB | |
| SCHEMBL1715779 | 0.82 | KIT (0.46) | KITBRAFAURKAAURKB | |
| SCHEMBL12204355 | 0.82 | KIT (0.42) | KITBRAFAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034811-B2 | Hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA A/S (DK) | 2011-10-11 | — | — | US | claimed |
| EP-1697312-B1 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2011-07-20 | — | — | EP | claimed |
| US-8034811-B2 | Hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA A/S (DK) | 2011-10-11 | — | — | US | disclosed |
| EP-1697312-B1 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2011-07-20 | — | — | EP | disclosed |