Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 7/20 | 0.68 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.62 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.61 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.60 |
| ▸ | AMD1 | P17707 | 2/20 | 0.60 |
| ▸ | WDR5 | P61964 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.57 |
| ▸ | DPY30 | Q9C005 | 1/20 | 0.57 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.57 |
| ▸ | PRMT7 | Q9NVM4 | 2/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970136 | 1.00 | DOT1L (0.68) | DOT1LCARM1EZH2TRDMT1AMD1 | |
| SCHEMBL9970144 | 0.93 | DOT1L (0.69) | DOT1LCARM1EZH2AMD1PRMT7 | |
| SCHEMBL16129509 | 0.93 | DOT1L (0.69) | DOT1LCARM1EZH2AMD1PRMT7 | |
| SCHEMBL19125218 | 0.91 | DOT1L (0.67) | DOT1LCARM1EZH2AMD1PRMT7 | |
| SCHEMBL15829367 | 0.91 | DOT1L (0.82) | DOT1LCARM1EZH2TRDMT1AMD1 | |
| SCHEMBL9970151 | 0.91 | DOT1L (0.82) | DOT1LCARM1EZH2TRDMT1AMD1 | |
| SCHEMBL19111299 | 0.90 | PRMT7 (0.67) | DOT1LCARM1EZH2TRDMT1AMD1 | |
| SCHEMBL9970166 | 0.90 | PI4KA (0.57) | DOT1LCARM1EZH2TRDMT1AMD1 | |
| SCHEMBL9970335 | 0.88 | DOT1L (0.73) | DOT1LCARM1EZH2AMD1WDR5 | |
| SCHEMBL17153319 | 0.87 | DOT1L (0.66) | DOT1LCARM1EZH2AMD1PRMT7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150284422-A1 | INHIBITORS OF PROTEIN METHYLTRANSFERASE DOT1L AND METHODS OF USE THEREOF | Epizyme, Inc. | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284422-A1 | INHIBITORS OF PROTEIN METHYLTRANSFERASE DOT1L AND METHODS OF USE THEREOF | DOT1L, PRMT1, CARM1 | DOT1L 1/4885CARM1 3/4885EZH2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.