SCHEMBL17153252

SCHEMBL17153252

Nc1nc(=O)n(C2CC(O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)cc1C#CCCOO

nearest known ligand 0.49

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLG P54098 2/20 0.48
POLB P06746 3/20 0.47
P2RY2 P41231 2/20 0.47
P2RY4 P51582 2/20 0.47
P2RY6 Q15077 2/20 0.47
DTYMK P23919 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17124949 0.94 POLG (0.49) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL21503943 0.94 POLG (0.48) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL17124951 0.92 POLG (0.47) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL18649867 0.92 POLG (0.46) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL18952763 0.91 POLG (0.50) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL5664015 0.90 POLG (0.51) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL10022245 0.90 POLG (0.51) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL22327108 0.90 POLG (0.51) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL5664002 0.90 POLG (0.51) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL8417580 0.90 POLG (0.51) POLGPOLBP2RY2P2RY4P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015153510-A1 MODIFIED CYTOSINE POLYNUCLEOTIDE OLIGOMERS AND METHODS CEPHEID (US) 2015-10-08 WO disclosed