Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.34 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17155169 | 0.84 | HTR2C (0.45) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| SCHEMBL17154232 | 0.81 | HTR2C (0.42) | HTR2CSIGMAR1MAPTEHMT2EHMT1 | |
| SCHEMBL16154955 | 0.78 | HTR2C (0.45) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| SCHEMBL14904919 | 0.75 | HTR2C (0.49) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| SCHEMBL20841540 | 0.73 | RGS12 (0.31) | — | |
| SCHEMBL17154231 | 0.72 | HTR2C (0.51) | HTR2CSIGMAR1MAPTHTR6HTR2A | |
| SCHEMBL14704897 | 0.72 | HTR2C (0.49) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| SCHEMBL6278677 | 0.72 | HTR2C (0.53) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| SCHEMBL14704895 | 0.72 | CCNT1 (0.49) | HTR2CSIGMAR1KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6795900 | 0.71 | HTR2C (0.78) | HTR2CSIGMAR1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9388179-B2 | N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels | MERCK SHARP & DOHME CORP. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150284389-A1 | N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284389-A1 | N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | SCN1B, SCN1A, SCN2B | HTR2C 436/4885SIGMAR1 1771/4885KDM4E 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.