Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 20/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.61 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.61 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.61 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.61 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.61 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.61 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714366 | 1.00 | SSTR3 (0.64) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| SCHEMBL12912368 | 0.91 | SSTR3 (0.70) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| Fumaric Acid SCHEMBL6714201 | 0.87 | SSTR3 (0.64) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| Fumaric Acid SCHEMBL6714206 | 0.87 | SSTR3 (0.64) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| SCHEMBL12890523 | 0.80 | SSTR3 (0.70) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| SCHEMBL1244095 | 0.80 | SSTR3 (0.70) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| SCHEMBL6715730 | 0.78 | SSTR3 (1.00) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| SCHEMBL12377679 | 0.77 | SSTR3 (0.71) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| SCHEMBL13244720 | 0.77 | SSTR3 (0.50) | SSTR3KCNH2SSTR4SSTR5CACNA1F | |
| SCHEMBL6713964 | 0.75 | SSTR3 (0.69) | SSTR3KCNH2SSTR4SSTR5CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377578-B1 | BETA-CARBOLINE DERIVATIVES AND ITS PHARMACEUTICAL USE AGAINST DEPRESSION AND ANXIETY | NOVARTIS AG (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-6861430-B2 | β-carboline derivatives and its pharmaceutical use against depression and anxiety | NOVARTIS AG (CH) | 2005-03-01 | — | — | US | disclosed |