Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ABAT | P80404 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156305 | 0.85 | DHODH (0.63) | DHODHTMEM97MEN1KMT2AADRB3 | |
| SCHEMBL17156388 | 0.83 | DHODH (0.46) | DHODHTMEM97SLC9A1ADRB3ADRA1D | |
| SCHEMBL17156134 | 0.81 | DHODH (0.50) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156094 | 0.81 | DHODH (0.50) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156402 | 0.81 | DHODH (0.44) | DHODHTMEM97MEN1KMT2ANTRK1 | |
| SCHEMBL17156274 | 0.80 | DHODH (0.62) | DHODHTMEM97MEN1KMT2AADRB3 | |
| SCHEMBL17156196 | 0.79 | DHODH (0.59) | DHODHTMEM97MEN1KMT2AADRB3 | |
| SCHEMBL17156427 | 0.79 | DHODH (0.43) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156288 | 0.79 | DHODH (0.60) | DHODHTMEM97MEN1KMT2AADRB3 | |
| SCHEMBL17156338 | 0.79 | DHODH (0.54) | DHODHTMEM97MEN1KMT2AADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |