Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.58 |
| ▸ | BRAF | P15056 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | ARAF | P10398 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA7 | P43166 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15094332 | 0.92 | SCN9A (0.66) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| Diethylamine SCHEMBL17158631 | 0.89 | SCN9A (0.61) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| Diethylamine SCHEMBL17158640 | 0.88 | SCN9A (0.61) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| SCHEMBL371116 | 0.83 | SCN9A (0.67) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| SCHEMBL15093801 | 0.81 | SCN9A (0.67) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| SCHEMBL15094343 | 0.81 | SCN9A (0.68) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| SCHEMBL16319527 | 0.81 | SCN9A (0.53) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| SCHEMBL371316 | 0.78 | SCN9A (0.50) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| SCHEMBL364772 | 0.75 | RAF1 (0.53) | SCN9ABRAFHDAC1SCN5ARAF1 | |
| SCHEMBL9106278 | 0.74 | ESRRA (0.57) | SCN9ABRAFHDAC1SCN5ARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150291514-A1 | N-Aminosulfonyl Benzamides | PFIZER LIMTED (GB) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291514-A1 | N-Aminosulfonyl Benzamides | SCN7A, SCN2B, SCN1B | SCN9A 14/4885BRAF 450/4885HDAC1 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.