SCHEMBL17159366

SCHEMBL17159366

NC1CCC(N[C@@H]2C[C@H]2c2cc(C(=O)NC3CCC(F)(F)CC3)cs2)CC1

nearest known ligand 0.78

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.78
MAOA P21397 6/20 0.61
KDM1A O60341 15/20 0.60
RCOR1 Q9UKL0 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17159368 1.00 MAOB (0.78) MAOBMAOAKDM1ARCOR1
SCHEMBL17159209 1.00 MAOB (0.78) MAOBMAOAKDM1ARCOR1
SCHEMBL18167491 1.00 MAOB (0.78) MAOBMAOAKDM1ARCOR1
Hydrochloric Acid SCHEMBL17159153 0.99 MAOB (0.77) MAOBMAOAKDM1ARCOR1
Hydrochloric Acid SCHEMBL17158959 0.99 MAOB (0.77) MAOBMAOAKDM1ARCOR1
Hydrochloric Acid SCHEMBL17158961 0.99 MAOB (0.77) MAOBMAOAKDM1ARCOR1
SCHEMBL17158831 0.93 MAOB (0.76) MAOBMAOAKDM1ARCOR1
SCHEMBL17158759 0.91 MAOB (0.83) MAOBMAOAKDM1ARCOR1
SCHEMBL26428143 0.90 MAOB (0.78) MAOBMAOAKDM1ARCOR1
SCHEMBL17159138 0.88 MAOB (1.00) MAOBMAOAKDM1ARCOR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230127775-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYLOIDOSIS ULTRAGENYX PHARMACEUTICAL INC. 2023-04-27 US disclosed
US-20210228694-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYLOIDOSIS ULTRAGENYX PHARMACEUTICAL INC. 2021-07-29 US disclosed
US-20210179603-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2021-06-17 US disclosed
US-20210179603-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2021-06-17 US disclosed
US-10968213-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-04-06 US disclosed
US-10968213-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-04-06 US disclosed
US-20190315735-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2019-10-17 US disclosed
US-20190315735-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2019-10-17 US disclosed
US-10414761-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-09-17 US disclosed
US-10414761-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-09-17 US disclosed
US-9487511-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-11-08 US disclosed
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20160311814-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20160311814-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20160311814-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-15 US disclosed
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-15 US disclosed
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315735-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOB 495/4885MAOA 493/4885KDM1A 1/4885
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOB 495/4885MAOA 493/4885KDM1A 1/4885
US-20230127775-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYLOIDOSIS GAA, LIPA, TTR MAOB 236/4885MAOA 317/4885KDM1A 2377/4885
US-20210179603-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOB 495/4885MAOA 493/4885KDM1A 1/4885
US-20210228694-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYLOIDOSIS GAA, LIPA, TTR MAOB 236/4885MAOA 317/4885KDM1A 2377/4885
US-10968213-B2 Cyclopropanamine compound and use thereof KDM1A, KDM1B, KDM2A MAOB 495/4885MAOA 493/4885KDM1A 1/4885
US-10414761-B2 Cyclopropanamine compound and use thereof KDM1A, KDM1B, KDM2A MAOB 495/4885MAOA 493/4885KDM1A 1/4885
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOB 495/4885MAOA 493/4885KDM1A 1/4885
US-20160311814-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOB 495/4885MAOA 493/4885KDM1A 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.