Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.89 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | ESRRG | P62508 | 3/20 | 0.70 |
| ▸ | HTR6 | P50406 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | PGR | P06401 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | GBA1 | P04062 | 1/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.70 |
| ▸ | PRKCG | P05129 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17164708 | 1.00 | ESR1 (0.89) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL10829107 | 0.94 | ESR1 (1.00) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL10048291 | 0.94 | ESR1 (1.00) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL20224018 | 0.91 | ESR1 (0.78) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL18872440 | 0.90 | ESR1 (0.81) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL23583980 | 0.85 | ESR1 (0.73) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL21538260 | 0.85 | ESR1 (0.73) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL1394284 | 0.84 | ESR1 (0.75) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL30353017 | 0.84 | ESR1 (0.68) | ESR1ESR2MAPTESRRGHTR6 | |
| SCHEMBL1394286 | 0.84 | ESR1 (0.75) | ESR1ESR2MAPTESRRGHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250255959-A1 | A SYSTEM FOR DRUG-INDUCIBLE EXPRESSION OF A POLYNUCLEOTIDE | Miltenyi Biotec B.V. & Co. KG (DE) | 2025-08-14 | — | — | US | disclosed |
| US-20250074959-A1 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A TRANSCRIPTION FACTOR AND A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2025-03-06 | — | — | US | disclosed |
| EP-4504243-A1 | A SYSTEM FOR DRUG-INDUCIBLE EXPRESSION OF A POLYNUCLEOTIDE | Miltenyi Biotec B.V. & Co. KG (DE) | 2025-02-12 | — | — | EP | disclosed |
| US-12202897-B2 | Drug regulated transgene expression | SEATTLE CHILDREN'S HOSPITAL (US) | 2025-01-21 | — | — | US | disclosed |
| US-20240226160-A9 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2024-07-11 | — | — | US | disclosed |
| CN-110291200-B | Agent ligand induction of transgene expression in mammalian cells | 西雅图儿童医院（DBA西雅图儿童研究所） | 2024-05-14 | — | — | CN | disclosed |
| US-20240131072-A1 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2024-04-25 | — | — | US | disclosed |
| EP-4341283-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A TRANSCRIPTION FACTOR AND A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) | 2024-03-27 | — | — | EP | disclosed |
| EP-4291571-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) | 2023-12-20 | — | — | EP | disclosed |
| CN-117177989-A | Activity-inducible fusion proteins with heat shock protein 90 binding domain | 西雅图儿童医院以西雅图儿童研究机构名义经营 | 2023-12-05 | — | — | CN | disclosed |
| WO-2018111763-A9 | CHIMERIC TRANSCRIPTION FACTOR VARIANTS WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF TRANSGENE EXPRESSION IN MAMMALIAN CELLS | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2018-07-19 | — | — | WO | disclosed |
| WO-2018111763-A1 | CHIMERIC TRANSCRIPTION FACTOR VARIANTS WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF TRANSGENE EXPRESSION IN MAMMALIAN CELLS | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2018-06-21 | — | — | WO | disclosed |
| CN-108174604-A | For the bispecific CAR T cells of solid tumor targeting | 西雅图儿童医院（DBA西雅图儿童研究所） | 2018-06-15 | — | — | CN | disclosed |
| EP-3331920-A1 | BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING | Seattle Children's Hospital, dba Seattle Children's Research Institute (US) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017123548-A1 | TUMOR-SPECIFIC IFNA SECRETION BY CAR T-CELLS TO REPROGRAM THE SOLID TUMOR MICROENVIRONMENT | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2017-07-20 | — | — | WO | disclosed |
| US-20170152297-A1 | DRUG REGULATED TRANSGENE EXPRESSION | Seattle Children's Hospital (dba Seattle Children's Research Institute) | 2017-06-01 | — | — | US | disclosed |
| CN-106573969-A | Drug-related transgene expression | 西雅图儿童医院（DBA西雅图儿童研究所） | 2017-04-19 | — | — | CN | disclosed |
| WO-2017027291-A1 | BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2017-02-16 | — | — | WO | disclosed |
| EP-3129399-A1 | DRUG RELATED TRANSGENE EXPRESSION | Seattle Children's Hospital, dba Seattle Children's Research Institute (US) | 2017-02-15 | — | — | EP | disclosed |
| WO-2015157432-A1 | DRUG RELATED TRANSGENE EXPRESSION | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2015-10-15 | — | — | WO | disclosed |