Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.78 |
| ▸ | STK3 | Q13188 | 7/20 | 0.78 |
| ▸ | STK26 | Q9P289 | 4/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15401258 | 0.88 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15400611 | 0.88 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15401040 | 0.87 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL18967695 | 0.86 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15401366 | 0.86 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15401754 | 0.86 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15400876 | 0.86 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15401225 | 0.86 | LRRK2 (0.77) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15402058 | 0.84 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 | |
| SCHEMBL15400854 | 0.84 | LRRK2 (1.00) | LRRK2STK3STK26CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156845-B2 | 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors | PFIZER INC. (US) | 2015-10-13 | — | — | US | disclosed |
| US-9156845-B2 | 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors | PFIZER INC. (US) | 2015-10-13 | — | — | US | disclosed |