SCHEMBL17166366

SCHEMBL17166366

Cc1ccc(N[C@H]2CCC[C@@H]2NC(=O)c2ccccc2-c2ncccn2)nc1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 20/20 0.72
HCRTR2 O43614 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17017371 1.00 HCRTR1 (0.72) HCRTR1HCRTR2
SCHEMBL17017407 0.89 HCRTR1 (0.74) HCRTR1HCRTR2
SCHEMBL17166367 0.86 HCRTR1 (0.76) HCRTR1HCRTR2
SCHEMBL17017372 0.86 HCRTR1 (0.76) HCRTR1HCRTR2
SCHEMBL17007288 0.84 HCRTR1 (1.00) HCRTR1HCRTR2
SCHEMBL17021483 0.84 HCRTR1 (1.00) HCRTR1HCRTR2
SCHEMBL17028077 0.84 HCRTR1 (1.00) HCRTR1HCRTR2
SCHEMBL17017423 0.83 HCRTR1 (0.71) HCRTR1HCRTR2
SCHEMBL17017436 0.82 HCRTR1 (0.79) HCRTR1HCRTR2
SCHEMBL17017366 0.81 HCRTR1 (0.78) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9156829-B2 Cycloalkyl and heterocycloalkyl compounds as orexin receptor antagonists TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-13 US disclosed