Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 16/20 | 1.00 |
| ▸ | PDE1A | P54750 | 1/20 | 0.78 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1716718 | 1.00 | PDE9A (1.00) | PDE9APDE1CPDE1APDE1BHDAC1 | |
| SCHEMBL1717044 | 0.92 | PDE9A (1.00) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL15996122 | 0.92 | PDE9A (1.00) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL12572133 | 0.92 | PDE9A (0.96) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL1716551 | 0.91 | PDE9A (1.00) | PDE9APDE1CPDE1APDE1BHDAC1 | |
| SCHEMBL17390226 | 0.91 | PDE9A (0.85) | PDE9APDE1CPDE1APDE1BHDAC1 | |
| SCHEMBL1717521 | 0.90 | PDE9A (1.00) | PDE9APDE1CPDE1APDE1BHDAC1 | |
| SCHEMBL30947582 | 0.90 | PDE9A (1.00) | PDE9APDE1CPDE1APDE1BHDAC1 | |
| SCHEMBL3727052 | 0.90 | PDE9A (1.00) | PDE9APDE1CPDE1APDE1BHDAC1 | |
| SCHEMBL1716516 | 0.90 | PDE9A (1.00) | PDE9APDE1CPDE1APDE1BHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152712-B1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER (US) | 2012-01-11 | — | — | EP | claimed |
| US-7964607-B2 | Pyrazolo[3,4-d]pyrimidine compounds | PFIZER INC. (US) | 2011-06-21 | — | — | US | claimed |
| US-20090030003-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC | 2009-01-29 | — | — | US | claimed |
| US-20250360137-A1 | ENHANCEMENT OF THE EFFICACY OF SEROTONERGIC PSYCHEDELIC DRUGS IN THE TREATMENT OR PREVENTION OF CERTAIN NEUROPSYCHIATRIC DISORDERS THROUGH INHIBITION OF TYPE-9 PHOSPHODIESTERASES | FREEDOM BIOSCIENCES INC (US) | 2025-11-27 | — | — | US | disclosed |
| EP-4618980-A1 | ENHANCEMENT OF THE EFFICACY OF SEROTONERGIC PSYCHEDELIC DRUGS IN THE TREATMENT OR PREVENTION OF CERTAIN NEUROPSYCHIATRIC DISORDERS THROUGH INHIBITION OF TYPE-9 PHOSPHODIESTERASES | Freedom Biosciences, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| WO-2025043067-A2 | PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS FOR THE TREATMENT OF CHRONIC HEART FAILURE | CARDURION PHARMACEUTICALS, INC. (US) | 2025-02-27 | — | — | WO | disclosed |
| WO-2024107445-A1 | ENHANCEMENT OF THE EFFICACY OF SEROTONERGIC PSYCHEDELIC DRUGS IN THE TREATMENT OR PREVENTION OF CERTAIN NEUROPSYCHIATRIC DISORDERS THROUGH INHIBITION OF TYPE-9 PHOSPHODIESTERASES | FREEDOM BIOSCIENCES, INC. (US) | 2024-05-23 | — | — | WO | disclosed |
| US-20240025904-A1 | PDE9 INHIBITORS FOR TREATING CARDIAC FAILURE | VANDERBILT UNIVERSITY | 2024-01-25 | — | — | US | disclosed |
| CN-116847846-A | PDE9 inhibitors for the treatment of heart failure | 卡都瑞恩医药公司 | 2023-10-03 | — | — | CN | disclosed |
| EP-4236951-A1 | PDE9 INHIBITORS FOR TREATING CARDIAC FAILURE | Cardurion Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093852-A1 | PDE9 INHIBITORS FOR TREATING CARDIAC FAILURE | Imara Inc. (US) | 2022-05-05 | — | — | WO | disclosed |
| EP-2152712-B1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER (US) | 2012-01-11 | — | — | EP | disclosed |
| US-7964607-B2 | Pyrazolo[3,4-d]pyrimidine compounds | PFIZER INC. (US) | 2011-06-21 | — | — | US | disclosed |
| US-7964607-B2 | Pyrazolo[3,4-d]pyrimidine compounds | PFIZER INC. (US) | 2011-06-21 | — | — | US | disclosed |
| US-7964607-B2 | Pyrazolo[3,4-d]pyrimidine compounds | PFIZER INC. (US) | 2011-06-21 | — | — | US | disclosed |
| EP-2152712-A1 | AMINO-HETEROCYCLIC COMPOUNDS | Pfizer Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| US-20090030003-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC | 2009-01-29 | — | — | US | disclosed |
| US-20090030003-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC | 2009-01-29 | — | — | US | disclosed |
| US-20090030003-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC | 2009-01-29 | — | — | US | disclosed |
| WO-2008139293-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250360137-A1 | ENHANCEMENT OF THE EFFICACY OF SEROTONERGIC PSYCHEDELIC DRUGS IN THE TREATMENT OR PREVENTION OF CERTAIN NEUROPSYCHIATRIC DISORDERS THROUGH INHIBITION OF TYPE-9 PHOSPHODIESTERASES | PDE9A, PDE3A, PDE2A | PDE9A 1/4885PDE1C 59/4885PDE1A 30/4885 |
| US-20090030003-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PDE9A, PDE2A, PDE10A | PDE9A 1/4885PDE1C 29/4885PDE1A 26/4885 |
| US-20240025904-A1 | PDE9 INHIBITORS FOR TREATING CARDIAC FAILURE | PDE9A, PDE2A, PDE5A | PDE9A 1/4885PDE1C 16/4885PDE1A 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.