Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18623934 | 1.00 | KCNN4 (0.35) | KCNN4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15904435 | 0.90 | KCNN4 (0.35) | KCNN4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15904331 | 0.90 | KCNN4 (0.35) | KCNN4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL18623896 | 0.83 | HDAC3 (0.34) | KCNN4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL17118662 | 0.79 | KCNN4 (0.34) | KCNN4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL17169288 | 0.78 | KCNN4 (0.33) | KCNN4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL17169224 | 0.78 | — | — | |
| SCHEMBL17169108 | 0.74 | KCNN4 (0.33) | KCNN4KCNE1KCNQ1 | |
| SCHEMBL17254207 | 0.73 | HDAC3 (0.37) | KCNN4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL12980340 | 0.73 | HDAC3 (0.37) | KCNN4HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015156421-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-10-15 | — | — | WO | disclosed |