Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1717038 | 1.00 | MAPK1 (0.40) | MAPK1MEN1LMNAKMT2AAURKA | |
| SCHEMBL1456451 | 0.93 | PIM1 (0.46) | MAPK1AURKAAURKBMAPK14PIM1 | |
| SCHEMBL1456453 | 0.93 | PIM1 (0.46) | MAPK1AURKAAURKBMAPK14PIM1 | |
| SCHEMBL1454811 | 0.92 | AURKA (0.39) | MAPK1AURKAAURKBMAPK14PIM1 | |
| SCHEMBL1456055 | 0.92 | AURKA (0.39) | MAPK1AURKAAURKBMAPK14PIM1 | |
| SCHEMBL1454812 | 0.92 | AURKA (0.39) | MAPK1AURKAAURKBMAPK14PIM1 | |
| SCHEMBL1456327 | 0.88 | MEN1 (0.44) | MAPK1MEN1LMNAKMT2AMAPK14 | |
| SCHEMBL1456325 | 0.88 | MEN1 (0.44) | MAPK1MEN1LMNAKMT2AMAPK14 | |
| SCHEMBL1455204 | 0.88 | KDM4E (0.41) | AURKAAURKBPIM1AKT2CDK1 | |
| SCHEMBL1455481 | 0.87 | AURKA (0.36) | MEN1KMT2AAURKAAURKBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979348-B1 | ANTI-VIRAL COMPOUNDS | ABBOTT LAB (US) | 2012-01-18 | — | — | EP | disclosed |