Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17173171 | 1.00 | PIK3R1 (0.39) | PIK3R1PIK3CAEPHX2HRH3CNR2 | |
| SCHEMBL17176111 | 0.84 | PIK3R1 (0.45) | PIK3R1PIK3CAEPHX2HRH3CNR2 | |
| SCHEMBL17176113 | 0.84 | PIK3R1 (0.45) | PIK3R1PIK3CAEPHX2HRH3CNR2 | |
| SCHEMBL17173056 | 0.84 | GRM5 (0.42) | HRH3ALDH1A1GRM5LMNAMAPK1 | |
| SCHEMBL17173068 | 0.81 | GRM5 (0.51) | HRH3ALDH1A1CYP2C19GRM5LMNA | |
| SCHEMBL17173065 | 0.81 | GRM5 (0.51) | HRH3ALDH1A1CYP2C19GRM5LMNA | |
| SCHEMBL17173082 | 0.80 | PIK3R1 (0.34) | PIK3R1PIK3CAHRH3ALDH1A1CYP2C19 | |
| SCHEMBL25810418 | 0.79 | EPHX2 (0.43) | PIK3R1PIK3CAEPHX2HRH3CNR2 | |
| SCHEMBL17173069 | 0.77 | PIK3R1 (0.34) | PIK3R1PIK3CAGRM5 | |
| SCHEMBL17173080 | 0.77 | PIK3R1 (0.34) | PIK3R1PIK3CAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260439-B2 | Dihydropyrrolopyrimidine derivatives | PFIZER INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | PFIZER (US) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | DPYD, TPD52L2, DTYMK | PIK3R1 2181/4885PIK3CA 1837/4885EPHX2 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.