Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17164241 | 0.93 | MRGPRX4 (0.53) | MRGPRX4 | |
| SCHEMBL30506562 | 0.93 | MRGPRX4 (0.53) | MRGPRX4 | |
| SCHEMBL17176194 | 0.90 | MRGPRX4 (0.53) | GRM2MRGPRX4 | |
| SCHEMBL17164317 | 0.88 | GRM2 (0.53) | GRM2 | |
| SCHEMBL17164328 | 0.88 | GRM2 (0.55) | GRM2 | |
| SCHEMBL17176197 | 0.87 | GRM2 (0.53) | GRM2 | |
| SCHEMBL17176478 | 0.86 | — | — | |
| SCHEMBL17176158 | 0.85 | GRM2 (0.54) | GRM2 | |
| SCHEMBL17164267 | 0.85 | — | — | |
| SCHEMBL17164281 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129345-B1 | METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS) AND USES THEREOF | SANFORD BURNHAM MED RES INST (US) | 2023-03-15 | — | — | EP | disclosed |
| US-10377695-B2 | Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-08-13 | — | — | US | disclosed |
| US-10377695-B2 | Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-08-13 | — | — | US | disclosed |
| US-10099993-B2 | Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2018-10-16 | — | — | US | disclosed |
| US-20180194710-A1 | Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof | Sanford Burnham Prebys Medical Discovery Institute | 2018-07-12 | — | — | US | disclosed |
| US-20180194710-A1 | Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof | Sanford Burnham Prebys Medical Discovery Institute | 2018-07-12 | — | — | US | disclosed |
| US-20170036987-A1 | Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-02-09 | — | — | US | disclosed |
| US-20170036987-A1 | Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-02-09 | — | — | US | disclosed |
| WO-2015157187-A1 | METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS) AND USES THEREOF | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170036987-A1 | Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof | GRM3, GRM2, GRM1 | GRM2 2/4885MRGPRX4 289/4885 |
| US-10377695-B2 | Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof | GRM3, GRM2, GRM1 | GRM2 2/4885MRGPRX4 289/4885 |
| US-10099993-B2 | Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof | GRM3, GRM2, GRM1 | GRM2 2/4885MRGPRX4 289/4885 |
| US-20180194710-A1 | Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof | GRM3, GRM2, GRM1 | GRM2 2/4885MRGPRX4 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.