Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 10/20 | 0.51 |
| ▸ | DRD3 | P35462 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | DRD5 | P21918 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18202990 | 0.85 | HTT (0.62) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL18199701 | 0.80 | HTT (0.55) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL19323807 | 0.80 | HTT (0.55) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL31653519 | 0.79 | HTT (0.62) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL7654044 | 0.76 | HTT (0.68) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL7050984 | 0.76 | HTT (0.72) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL21581203 | 0.75 | DRD4 (0.59) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL8168957 | 0.74 | HTT (0.70) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL2975841 | 0.74 | HTT (0.70) | HTTDRD4DRD3SMN1; SMN2HSD17B10 | |
| SCHEMBL12424273 | 0.74 | JAK2 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170066732-A1 | ANTI-ENTEROVIRUS 71 THIADIAZOLIDINE DERIVATIVE | Jiangsu Kanion pharmaceutical CO. LTD (CN) | 2017-03-09 | — | — | US | disclosed |
| WO-2016124129-A1 | DIAZA-BENZOFLUORANTHRENE COMPOUNDS | 南京明德新药研发股份有限公司 | 2016-08-11 | — | — | WO | disclosed |
| WO-2016008381-A1 | PYRIDINE DERIVATIVES AND ANTI-MYCOBACTERIAL USE THEREOF | 辰欣药业股份有限公司 | 2016-01-21 | — | — | WO | disclosed |
| WO-2015192760-A1 | PYRIDINO[1,2-A]PYRIMIDONE ANALOGUE USED AS PI3K INHIBITOR | 南京明德新药研发股份有限公司 | 2015-12-23 | — | — | WO | disclosed |
| WO-2015165340-A1 | ANTI-ENTEROVIRUS 71 THIADIAZOLIDINE DERIVATIVE | 南京明德新药研发股份有限公司 | 2015-11-05 | — | — | WO | disclosed |
| WO-2015154630-A1 | ANALOGUES OF 4H-PYRAZOLO[1,5-Α]BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS | 南京明德新药研发股份有限公司 | 2015-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066732-A1 | ANTI-ENTEROVIRUS 71 THIADIAZOLIDINE DERIVATIVE | EIF2AK2, GTF3C5, GTF3C1 | HTT 4098/4885DRD4 1552/4885DRD3 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.