Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 14/20 | 0.41 |
| ▸ | CBLB | Q13191 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945431 | 0.86 | MAP3K5 (0.56) | MAP3K5CBLB | |
| SCHEMBL17180512 | 0.84 | MAP3K5 (0.53) | MAP3K5CBLB | |
| SCHEMBL946376 | 0.75 | MAP3K5 (0.52) | MAP3K5 | |
| SCHEMBL943925 | 0.75 | MAP3K5 (0.60) | MAP3K5CBLBTNFSMN1; SMN2 | |
| SCHEMBL23721197 | 0.74 | CBLB (0.31) | MAP3K5CBLB | |
| SCHEMBL934954 | 0.74 | MAP3K5 (0.47) | MAP3K5TNF | |
| SCHEMBL944333 | 0.71 | MAP3K5 (0.60) | MAP3K5CBLB | |
| SCHEMBL945552 | 0.71 | MAP3K5 (0.63) | MAP3K5CBLBTNFSMN1; SMN2 | |
| SCHEMBL12943387 | 0.70 | MAP3K5 (0.45) | MAP3K5 | |
| SCHEMBL945392 | 0.70 | MAP3K5 (0.58) | MAP3K5CBLBTNFSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2933252-A1 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2015-10-21 | — | — | EP | disclosed |