Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 18/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17180816 | 0.94 | EIF4E (0.74) | EIF4E | |
| SCHEMBL17180823 | 0.92 | EIF4E (0.72) | EIF4EKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL17180817 | 0.91 | EIF4E (0.75) | EIF4E | |
| SCHEMBL17180824 | 0.90 | EIF4E (0.59) | EIF4EKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL17180768 | 0.90 | EIF4E (0.74) | EIF4E | |
| SCHEMBL17180786 | 0.90 | EIF4E (0.74) | EIF4E | |
| SCHEMBL17180796 | 0.90 | EIF4E (0.74) | EIF4E | |
| SCHEMBL17180788 | 0.88 | EIF4E (0.77) | EIF4E | |
| SCHEMBL17180783 | 0.88 | EIF4E (0.77) | EIF4E | |
| SCHEMBL17180736 | 0.87 | EIF4E (0.72) | EIF4EKDM4ENPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758380-B1 | BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS | HOFFMANN LA ROCHE (CH) | 2015-10-21 | — | — | EP | claimed |