Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 18/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17180799 | 0.92 | EIF4E (0.81) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL17180810 | 0.91 | EIF4E (0.80) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL17180749 | 0.91 | EIF4E (0.78) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL14797325 | 0.90 | EIF4E (1.00) | EIF4E | |
| SCHEMBL17180822 | 0.89 | EIF4E (0.80) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL17180829 | 0.87 | EIF4E (0.81) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL17180733 | 0.86 | EIF4E (0.80) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL17180707 | 0.86 | EIF4E (0.79) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL17180766 | 0.85 | EIF4E (0.79) | EIF4ECYP3A4MEN1LMNAPOLB | |
| SCHEMBL17180704 | 0.85 | EIF4E (0.78) | EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758380-B1 | BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS | HOFFMANN LA ROCHE (CH) | 2015-10-21 | — | — | EP | claimed |