Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101094 | 0.88 | GRM2 (0.71) | GRM2 | |
| SCHEMBL13232289 | 0.86 | GRM2 (0.71) | GRM2 | |
| SCHEMBL171929 | 0.85 | GRM2 (1.00) | GRM2 | |
| SCHEMBL101605 | 0.85 | GRM2 (0.77) | GRM2 | |
| SCHEMBL13232286 | 0.84 | GRM2 (0.69) | GRM2 | |
| SCHEMBL100668 | 0.84 | GRM2 (0.71) | GRM2 | |
| SCHEMBL101093 | 0.83 | GRM2 (0.69) | GRM2 | |
| SCHEMBL171270 | 0.81 | GRM2 (0.68) | GRM2 | |
| SCHEMBL103205 | 0.79 | GRM2 (1.00) | GRM2 | |
| SCHEMBL11959885 | 0.79 | GRM2 (0.70) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426125-A1 | 1,4 disubstituted 3 cyano pyridone derivatives and their use as positive allosteric modulators of mGluR2 receptors | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |