Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22454346 | 0.92 | NR5A1 (0.50) | HTR2AHTR2CHTR1BHTR2BNR5A1 | |
| SCHEMBL2676039 | 0.92 | NR5A1 (0.50) | HTR2AHTR2CHTR1BHTR2BNR5A1 | |
| SCHEMBL4754947 | 0.88 | NR5A1 (0.46) | HTR2AHTR2CHTR1BHTR2BNR5A1 | |
| SCHEMBL16265268 | 0.82 | RARB (0.43) | RARBCYP3A4CYP2D6HPGDKDM4E | |
| SCHEMBL17694325 | 0.81 | PTPN11 (0.45) | NR5A1RARBCYP3A4CYP2D6PTPN11 | |
| SCHEMBL17874480 | 0.78 | ESR1 (0.49) | CYP3A4CYP2D6HPGDALDH1A1L3MBTL1 | |
| SCHEMBL15559112 | 0.77 | NR5A1 (0.43) | HTR2AHTR2CHTR1BHTR2BNR5A1 | |
| SCHEMBL30372048 | 0.77 | NR5A1 (0.43) | HTR2AHTR2CHTR1BHTR2BNR5A1 | |
| SCHEMBL30475756 | 0.77 | NR5A1 (0.49) | NR5A1RARBCYP3A4CYP2D6HPGD | |
| SCHEMBL14182502 | 0.77 | NR5A1 (0.49) | NR5A1RARBCYP3A4CYP2D6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10923662-B2 | Fluoroalkylfluorene derivatives | LOMOX LIMITED (GB) | 2021-02-16 | — | — | US | disclosed |
| EP-3131898-B1 | FLUOROALKYLFLUORENE DERIVATIVES | LOMOX LTD (GB) | 2020-03-18 | — | — | EP | disclosed |
| US-10084137-B2 | Fluoroalkylfluorene derivatives | LOMOX LIMITED (GB) | 2018-09-25 | — | — | US | disclosed |
| US-20180261771-A1 | FLUOROALKYLFLUORENE DERIVATIVES | LOMOX LIMITED (GB) | 2018-09-13 | — | — | US | disclosed |
| EP-3131898-A1 | FLUOROALKYLFLUORENE DERIVATIVES | Lomox Limited (GB) | 2017-02-22 | — | — | EP | disclosed |
| US-20170033290-A1 | FLUOROALKYLFLUORENE DERIVATIVES | LOMOX LIMITED (GB) | 2017-02-02 | — | — | US | disclosed |
| US-20170033290-A1 | FLUOROALKYLFLUORENE DERIVATIVES | LOMOX LIMITED (GB) | 2017-02-02 | — | — | US | disclosed |
| WO-2015159098-A1 | FLUOROALKYLFLUORENE DERIVATIVES | LOMOX LIMITED (GB) | 2015-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10084137-B2 | Fluoroalkylfluorene derivatives | FLNB, AFF2, EFHD2 | HTR2A 1473/4885HTR2C 1959/4885HTR1B 531/4885 |
| US-20170033290-A1 | FLUOROALKYLFLUORENE DERIVATIVES | FLNB, AFF2, EFHD2 | HTR2A 1473/4885HTR2C 1959/4885HTR1B 531/4885 |
| US-10923662-B2 | Fluoroalkylfluorene derivatives | FLNB, AFF2, EFHD2 | HTR2A 1473/4885HTR2C 1959/4885HTR1B 531/4885 |
| US-20180261771-A1 | FLUOROALKYLFLUORENE DERIVATIVES | FLNB, AFF2, EFHD2 | HTR2A 1473/4885HTR2C 1959/4885HTR1B 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.