Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.47 |
| ▸ | APAF1 | O14727 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.47 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1947682 | 0.95 | KCNH2 (0.43) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL14773851 | 0.95 | KCNH2 (0.43) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL2595984 | 0.95 | KCNH2 (0.43) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL9482978 | 0.91 | TDP1 (0.49) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL9482974 | 0.91 | TDP1 (0.49) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL16181564 | 0.90 | HSD17B10 (0.46) | TDP1LMNAPLCG1L3MBTL1MAPT | |
| SCHEMBL2595316 | 0.89 | KCNH2 (0.44) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL2595314 | 0.89 | KCNH2 (0.44) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL14773850 | 0.89 | KCNH2 (0.44) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL5497465 | 0.88 | TDP1 (0.62) | TDP1APAF1LMNATSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163034-B2 | Crystalline (6R,7R)-7-{2-(5-amino-[1,2,4] thiadiazol-3-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-[(R)-1′-tert-butoxycarbonyl-2-oxo-[1,3′]bipyrrolidinyl-(3E)-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; its manufacture and use | BASILEA PHARMACEUTICA AG (CH) | 2015-10-20 | — | — | US | disclosed |
| US-9163034-B2 | Crystalline (6R,7R)-7-{2-(5-amino-[1,2,4] thiadiazol-3-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-[(R)-1′-tert-butoxycarbonyl-2-oxo-[1,3′]bipyrrolidinyl-(3E)-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; its manufacture and use | BASILEA PHARMACEUTICA AG (CH) | 2015-10-20 | — | — | US | disclosed |