Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CTRC | Q99895 | 1/20 | 0.45 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731862 | 0.86 | KDM4E (0.80) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL4738065 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL14014105 | 0.79 | KDM4E (0.85) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL14014099 | 0.79 | KDM4E (0.85) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL14014194 | 0.78 | KDM4E (0.82) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL1718615 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL14013916 | 0.76 | KDM4E (0.74) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL1718594 | 0.76 | TP53 (0.70) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL4214025 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL3708441 | 0.76 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |