Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719289 | 0.88 | KMT2A (0.57) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1717989 | 0.88 | KMT2A (0.58) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1718391 | 0.87 | KMT2A (0.60) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1719818 | 0.87 | MAPT (0.57) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1719596 | 0.85 | KMT2A (0.56) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1718640 | 0.85 | RXFP1 (0.66) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1718494 | 0.83 | KMT2A (0.55) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1718687 | 0.79 | KMT2A (0.55) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1719003 | 0.79 | KMT2A (0.55) | KMT2AMAPTRXFP1MEN1ALDH1A1 | |
| SCHEMBL1718002 | 0.79 | KMT2A (0.65) | KMT2AMAPTRXFP1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |