Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | HRH2 | P25021 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | DRD1 | P21728 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166802 | 0.92 | HRH4 (0.53) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL300115 | 0.92 | HRH4 (0.53) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL117910 | 0.90 | HRH4 (0.55) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL300555 | 0.87 | HRH4 (0.56) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL171955 | 0.87 | HRH4 (0.56) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL311644 | 0.87 | HRH4 (0.56) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL172313 | 0.87 | HRH4 (0.57) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL300263 | 0.87 | HRH4 (0.57) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL171981 | 0.87 | HRH4 (0.57) | HRH4DRD4DRD2HTR2CHTR2A | |
| SCHEMBL121951 | 0.86 | HRH4 (0.51) | HRH4DRD4DRD2HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137180-B1 | DIBENZO [B,F][1,4] OXAZAPINE COMPOUNDS | ARYX THERAPEUTICS INC (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2008112900-A1 | DIBENZO[B,F][1,4]OXAZAPINE COMPOUNDS | ARYX THERAPEUTICS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |