Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655662 | 0.95 | PI4KB (0.49) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL654507 | 0.95 | PI4KB (0.59) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL655515 | 0.87 | PI4KB (0.61) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL655283 | 0.84 | POLB (0.49) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL652838 | 0.83 | PI4KB (0.47) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL654810 | 0.82 | PI4KB (0.57) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL654775 | 0.81 | PI4KB (0.59) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL4113637 | 0.80 | PI4KB (0.63) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL655731 | 0.79 | PI4KB (0.59) | PI4KBPOLBMAPTLMNAMAPK1 | |
| SCHEMBL654267 | 0.79 | PI4KB (0.61) | PI4KBPOLBMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |