Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 1.00 |
| ▸ | BACE2 | Q9Y5Z0 | 10/20 | 1.00 |
| ▸ | KCNH1 | O95259 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | APP | P05067 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17210718 | 1.00 | BACE1 (1.00) | BACE1BACE2KCNH1KCNH2APP | |
| SCHEMBL12496846 | 1.00 | BACE1 (1.00) | BACE1BACE2KCNH1KCNH2APP | |
| SCHEMBL17210691 | 0.88 | BACE1 (0.79) | BACE1BACE2KCNH1KCNH2 | |
| SCHEMBL17210694 | 0.85 | BACE1 (0.74) | BACE1BACE2KCNH1KCNH2APP | |
| SCHEMBL17210677 | 0.81 | BACE1 (0.68) | BACE1BACE2KCNH1KCNH2APP | |
| SCHEMBL15400001 | 0.81 | BACE1 (0.68) | BACE1BACE2KCNH1KCNH2APP | |
| SCHEMBL12496958 | 0.81 | BACE1 (0.68) | BACE1BACE2KCNH1KCNH2APP | |
| SCHEMBL362142 | 0.78 | BACE1 (1.00) | BACE1BACE2KCNH1KCNH2APP | |
| SCHEMBL10295985 | 0.78 | BACE1 (0.67) | BACE1BACE2KCNH1KCNH2APP | |
| Hydrochloric Acid SCHEMBL1173583 | 0.78 | BACE1 (0.98) | BACE1BACE2KCNH1KCNH2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681219-B1 | 6,7-DIHYDRO-PYRAZOLO[1,5-A]PYRAZIN-4-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-28 | — | — | EP | disclosed |