Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 18/20 | 0.64 |
| ▸ | AKT1 | P31749 | 15/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 13/20 | 0.64 |
| ▸ | INCENP | Q9NQS7 | 12/20 | 0.64 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14983867 | 0.92 | RPS6KB1 (0.76) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL17200071 | 0.91 | AKT1 (0.63) | RPS6KB1AKT1AURKBINCENPAKT2 | |
| SCHEMBL17200080 | 0.90 | RPS6KB1 (0.62) | RPS6KB1AKT1AURKBINCENPAKT2 | |
| SCHEMBL17200084 | 0.85 | AKT1 (0.56) | RPS6KB1AKT1AURKBINCENPAKT2 | |
| SCHEMBL17200077 | 0.84 | RPS6KB1 (0.61) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL14983861 | 0.83 | RPS6KB1 (0.74) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL10093521 | 0.83 | RPS6KB1 (0.74) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL14983865 | 0.83 | AKT1 (0.75) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL10093513 | 0.82 | RPS6KB1 (0.74) | RPS6KB1AKT1AURKBINCENPAURKA | |
| SCHEMBL10093515 | 0.81 | RPS6KB1 (0.76) | RPS6KB1AKT1AURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598492-B1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2015-10-28 | — | — | EP | disclosed |