Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 13/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 11/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17200079 | 0.92 | AKT1 (0.60) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17200113 | 0.92 | RPS6KB1 (0.58) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17200091 | 0.92 | AKT1 (0.61) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17200107 | 0.90 | AKT1 (0.49) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865832 | 0.88 | AKT1 (0.66) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL10093517 | 0.87 | AKT1 (0.63) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL14983864 | 0.87 | AKT1 (0.63) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17200077 | 0.86 | RPS6KB1 (0.61) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17200084 | 0.84 | AKT1 (0.56) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865865 | 0.82 | AKT1 (0.66) | AKT1RPS6KB1AURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598492-B1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2015-10-28 | — | — | EP | claimed |