Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 17/20 | 0.76 |
| ▸ | AURKA | O14965 | 12/20 | 0.76 |
| ▸ | AKT1 | P31749 | 8/20 | 0.75 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.75 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10093523 | 1.00 | RPS6KB1 (0.76) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL527690 | 0.90 | RPS6KB1 (0.79) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL527028 | 0.89 | RPS6KB1 (0.73) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL17200096 | 0.87 | RPS6KB1 (0.68) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL10093516 | 0.87 | RPS6KB1 (0.68) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL666292 | 0.87 | RPS6KB1 (1.00) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL14974658 | 0.86 | RPS6KB1 (0.80) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL10093525 | 0.86 | RPS6KB1 (1.00) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL14974401 | 0.85 | RPS6KB1 (0.82) | RPS6KB1AURKAAKT1AURKBINCENP | |
| SCHEMBL10093526 | 0.85 | RPS6KB1 (0.82) | RPS6KB1AURKAAKT1AURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598492-B1 | BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K | MERCK PATENT GMBH (DE) | 2015-10-28 | — | — | EP | disclosed |