Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489091 | 0.92 | AURKA (0.78) | AURKAAURKB | |
| SCHEMBL5489301 | 0.91 | AURKA (0.75) | AURKAAURKB | |
| SCHEMBL5483626 | 0.90 | AURKA (0.75) | AURKAAURKB | |
| SCHEMBL3490186 | 0.89 | AURKA (0.83) | AURKAAURKB | |
| SCHEMBL5487348 | 0.88 | AURKA (0.72) | AURKAAURKB | |
| SCHEMBL5484970 | 0.88 | AURKA (0.75) | AURKAAURKB | |
| SCHEMBL3490982 | 0.86 | AURKA (0.85) | AURKAAURKB | |
| SCHEMBL3488772 | 0.86 | AURKA (0.71) | AURKAAURKB | |
| SCHEMBL3489013 | 0.86 | AURKA (0.68) | AURKAAURKB | |
| SCHEMBL5487339 | 0.86 | AURKA (0.74) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567358-B2 | Methods of treatment using N-(3-fluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-quinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide | ASTRAZENECA AB (SE) | 2017-02-14 | — | — | US | disclosed |
| US-20150307534-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307534-A1 | CHEMICAL COMPOUNDS | ABL1, NQO1, NQO2 | AURKA 492/4885AURKB 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.