Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 8/20 | 0.87 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.68 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.62 |
| ▸ | P2RY11 | Q96G91 | 4/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | CD99 | P14209 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17203005 | 1.00 | NT5E (0.87) | NT5EADORA3P2RY1P2RY11CA1 | |
| SCHEMBL17202527 | 1.00 | NT5E (0.87) | NT5EADORA3P2RY1P2RY11CA1 | |
| SCHEMBL17203009 | 1.00 | NT5E (0.87) | NT5EADORA3P2RY1P2RY11CA1 | |
| SCHEMBL17202524 | 1.00 | NT5E (0.87) | NT5EADORA3P2RY1P2RY11CA1 | |
| SCHEMBL17202697 | 1.00 | NT5E (0.87) | NT5EADORA3P2RY1P2RY11CA1 | |
| SCHEMBL30655874 | 1.00 | NT5E (0.87) | NT5EADORA3P2RY1P2RY11CA1 | |
| SCHEMBL17202815 | 1.00 | NT5E (0.87) | NT5EADORA3P2RY1P2RY11CA1 | |
| SCHEMBL19948904 | 0.93 | NT5E (1.00) | NT5EADORA3CD99ADORA2AADORA1 | |
| SCHEMBL19949301 | 0.93 | NT5E (1.00) | NT5EADORA3CD99ADORA2AADORA1 | |
| SCHEMBL30262579 | 0.93 | NT5E (1.00) | NT5EADORA3CD99ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3692068-A1 | RESTORATION OF T CELL ACTIVITY VIA THE CD39/CD73 AXIS | Innate Pharma (FR) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019068907-A1 | RESTORATION OF T CELL ACTIVITY VIA THE CD39/CD73 AXIS | INNATE PHARMA (FR) | 2019-04-11 | — | — | WO | disclosed |
| EP-3134411-A1 | PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER | Vitae Pharmaceuticals, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015164573-A1 | PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER | VITAE PHARMACEUTICALS, INC. (US) | 2015-10-29 | — | — | WO | disclosed |