Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 5/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 5/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720789 | 0.90 | EPHX2 (0.45) | EPHX2PLK1HDAC4HDAC1HDAC6 | |
| SCHEMBL1720447 | 0.76 | EPHX2 (0.46) | EPHX2HDAC4HDAC1HDAC6LATS1 | |
| SCHEMBL1720968 | 0.75 | EPHX2 (0.46) | EPHX2IDO1TDO2MEN1KMT2A | |
| SCHEMBL1720526 | 0.74 | EPHX2 (0.45) | EPHX2PLK1HDAC4HDAC1HDAC6 | |
| SCHEMBL1720565 | 0.74 | EPHX2 (0.45) | EPHX2PLK1PLK2KDM4E | |
| SCHEMBL1720568 | 0.72 | PLK1 (0.35) | PLK1HDAC4HDAC1HDAC6SOS1 | |
| SCHEMBL18878981 | 0.72 | EPHX2 (0.54) | EPHX2LATS1LATS2 | |
| SCHEMBL1721455 | 0.69 | EPHX2 (0.54) | EPHX2PLK1HDAC4HDAC1HDAC6 | |
| SCHEMBL1720909 | 0.68 | EPHX2 (0.64) | EPHX2HDAC4HDAC1HDAC6LATS1 | |
| SCHEMBL1720959 | 0.68 | SOS1 (0.39) | HDAC4HDAC1HDAC6SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406265-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | claimed |
| WO-2010102778-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | claimed |
| EP-2406265-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102778-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | disclosed |