Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 14/20 | 1.00 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17203299 | 0.82 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL17203305 | 0.81 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL17205667 | 0.78 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL6078847 | 0.76 | TRPV1 (0.84) | TRPV1 | |
| SCHEMBL14644383 | 0.75 | TRPV1 (0.70) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29594946 | 0.74 | TRPV1 (0.72) | TRPV1MMP2 | |
| SCHEMBL11875261 | 0.73 | TRPV1 (0.70) | TRPV1 | |
| SCHEMBL17203114 | 0.73 | TRPV1 (0.66) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8607007 | 0.71 | TRPV1 (0.64) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL11305715 | 0.69 | TSHR (0.69) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | claimed |
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | disclosed |
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | disclosed |