Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | IDE | P14735 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17202893 | 0.87 | TRPV1 (0.77) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL17205574 | 0.80 | TRPV1 (0.67) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL17203312 | 0.79 | TRPV1 (0.66) | TRPV1MAPTMEN1KMT2ALMNA | |
| SCHEMBL109158 | 0.79 | MAPT (0.73) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL107219 | 0.77 | MAPT (0.71) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL26393857 | 0.77 | TRPV1 (1.00) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL24649660 | 0.77 | MAPT (0.71) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL18273974 | 0.77 | TRPV1 (0.75) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL23417638 | 0.77 | MAPT (0.75) | TRPV1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL17205697 | 0.77 | TRPV1 (1.00) | TRPV1MEN1KMT2AHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | claimed |
| WO-2015162216-A1 | BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2015-10-29 | — | — | WO | disclosed |