Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 10/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656556 | 0.97 | EGFR (0.47) | CSNK2A2CSNK2BCSNK2A1FGFR1EGFR | |
| SCHEMBL656145 | 0.87 | FGFR1 (0.56) | CSNK2A2CSNK2BCSNK2A1FGFR1EGFR | |
| SCHEMBL18035922 | 0.83 | EGFR (0.43) | CSNK2A2CSNK2BCSNK2A1FGFR1EGFR | |
| SCHEMBL653492 | 0.83 | CSNK2A1 (0.48) | CSNK2A2CSNK2BCSNK2A1FGFR1EGFR | |
| SCHEMBL655312 | 0.79 | KDM4E (0.52) | MAPTL3MBTL1TP53SMN1; SMN2KDM4E | |
| SCHEMBL655151 | 0.75 | EGFR (0.47) | FGFR1EGFRKDRMAPT | |
| SCHEMBL656557 | 0.74 | FGFR1 (0.69) | FGFR1EGFRERBB2 | |
| SCHEMBL1720811 | 0.73 | EGFR (0.56) | FGFR1EGFRERBB2 | |
| SCHEMBL655984 | 0.67 | PI4KB (0.44) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL654671 | 0.67 | KDM4E (0.51) | MAPTL3MBTL1SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |