Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPA1 | O60313 | 1/20 | 0.71 |
| ▸ | EIF5B | O60841 | 1/20 | 0.71 |
| ▸ | MET | P08581 | 1/20 | 0.71 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.71 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395744 | 1.00 | OPA1 (0.71) | OPA1EIF5BMETHMOX2IDO1 | |
| SCHEMBL1395759 | 0.90 | OPA1 (0.80) | OPA1EIF5BMETHMOX2LMNA | |
| SCHEMBL1395844 | 0.88 | OPA1 (0.73) | OPA1EIF5BMETHMOX2IDO1 | |
| SCHEMBL1720547 | 0.84 | OPA1 (0.79) | OPA1EIF5BMETHMOX2IDO1 | |
| SCHEMBL1395776 | 0.84 | OPA1 (0.75) | OPA1EIF5BMETHMOX2MTNR1A | |
| SCHEMBL1395775 | 0.84 | OPA1 (0.63) | OPA1EIF5BMETHMOX2MTNR1A | |
| SCHEMBL15872111 | 0.84 | OPA1 (0.63) | OPA1EIF5BMETHMOX2MTNR1A | |
| Tivantinib SCHEMBL14865187 | 0.84 | OPA1 (1.00) | OPA1EIF5BMETHMOX2IDO1 | |
| Tivantinib SCHEMBL224883 | 0.84 | OPA1 (1.00) | OPA1EIF5BMETHMOX2IDO1 | |
| Tivantinib SCHEMBL45306 | 0.84 | OPA1 (1.00) | OPA1EIF5BMETHMOX2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846406-B9 | MALEIMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER | ARQULE INC (US) | 2012-01-11 | — | — | EP | disclosed |