Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRZ1 | P23471 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | USP1 | O94782 | 5/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720781 | 0.79 | EPHX2 (0.44) | PTPRZ1PTPN1EPHX2APPMAPT | |
| SCHEMBL1721575 | 0.79 | PTPRZ1 (0.43) | PTPRZ1PTPN1EPHX2MAPTMEN1 | |
| SCHEMBL2769324 | 0.78 | EPHX2 (0.70) | PTPRZ1PTPN1EPHX2APPMAPT | |
| SCHEMBL1721505 | 0.77 | EPHX2 (0.47) | PTPRZ1PTPN1EPHX2MAPTSMN1; SMN2 | |
| SCHEMBL2768550 | 0.73 | EPHX2 (0.50) | PTPRZ1PTPN1EPHX2USP1WDR48 | |
| SCHEMBL2768924 | 0.73 | EPHX2 (0.50) | PTPRZ1PTPN1EPHX2MEN1KMT2A | |
| SCHEMBL2767896 | 0.72 | EPHX2 (0.49) | PTPRZ1PTPN1EPHX2MEN1KMT2A | |
| SCHEMBL1721129 | 0.70 | EPHX2 (0.50) | PTPRZ1PTPN1EPHX2 | |
| SCHEMBL1720758 | 0.70 | EPHX2 (0.50) | PTPRZ1PTPN1EPHX2 | |
| SCHEMBL1720963 | 0.69 | EPHX2 (0.50) | PTPRZ1PTPN1EPHX2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406265-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | claimed |
| WO-2010102778-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | claimed |
| EP-2406265-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102778-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | disclosed |