Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 11/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698045 | 0.94 | CSF1R (0.66) | CSF1RKITBRAFKDRRAF1 | |
| SCHEMBL1697866 | 0.91 | BRAF (0.55) | CSF1RKITBRAFRAF1BTK | |
| SCHEMBL1697898 | 0.87 | KDM4E (0.68) | CSF1RKITBRAFKDRRAF1 | |
| SCHEMBL12065267 | 0.82 | BRAF (0.62) | CSF1RKITBRAFKDRRAF1 | |
| SCHEMBL1698110 | 0.82 | BRAF (0.54) | BRAFRAF1BTK | |
| SCHEMBL1697864 | 0.81 | BRAF (0.53) | BRAFRAF1BTK | |
| SCHEMBL1698025 | 0.81 | BRAF (0.53) | BRAFRAF1BTK | |
| SCHEMBL1697878 | 0.80 | BRAF (0.54) | BRAFRAF1BTK | |
| SCHEMBL1698082 | 0.80 | BRAF (0.51) | BRAFRAF1BTK | |
| SCHEMBL1697876 | 0.79 | BRAF (0.54) | CSF1RKITBRAFRAF1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576566-B1 | THIENO(2,3B)PYRAZINE COMPOUNDS AS B-RAF INHIBITORS | MERCK SHARP & DOHME (NL) | 2015-10-28 | — | — | EP | disclosed |