Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.64 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.61 |
| ▸ | ABL1 | P00519 | 6/20 | 0.61 |
| ▸ | BCR | P11274 | 6/20 | 0.61 |
| ▸ | KIT | P10721 | 4/20 | 0.57 |
| ▸ | CLK1 | P49759 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | STK25 | O00506 | 1/20 | 0.57 |
| ▸ | CIT | O14578 | 1/20 | 0.57 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | CHUK | O15111 | 1/20 | 0.57 |
| ▸ | MUSK | O15146 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27088109 | 0.90 | RET (0.64) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL14704589 | 0.90 | MKNK2 (0.65) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL3182950 | 0.89 | RET (0.63) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL16380144 | 0.89 | RET (0.63) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL15785403 | 0.89 | MKNK2 (0.65) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL16587846 | 0.88 | RET (0.68) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL12516824 | 0.88 | RET (0.62) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL31053458 | 0.86 | FGFR4 (0.61) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL14704625 | 0.85 | RET (0.59) | RETKDRMKNK2MKNK1ABL1 | |
| SCHEMBL16587312 | 0.85 | RET (0.64) | RETKDRMKNK2MKNK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |