Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.57 |
| ▸ | CDK9 | P50750 | 10/20 | 0.50 |
| ▸ | CDK1 | P06493 | 8/20 | 0.50 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.50 |
| ▸ | CCNK | O75909 | 6/20 | 0.50 |
| ▸ | CDK7 | P50613 | 4/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.50 |
| ▸ | GSK3A | P49840 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.50 |
| ▸ | CCNH | P51946 | 2/20 | 0.50 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.50 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322875 | 1.00 | CDK2 (0.57) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL10378376 | 0.92 | CDK2 (0.55) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL7886142 | 0.87 | CDK2 (0.51) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL7894521 | 0.84 | CDK2 (0.58) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL14194657 | 0.84 | CDK2 (0.56) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL14194742 | 0.83 | CDK2 (0.55) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL14194663 | 0.83 | CDK2 (0.52) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL14194686 | 0.83 | CDK2 (0.52) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL14194667 | 0.83 | CDK2 (0.52) | CDK2CDK5CCNE1CDK9CDK1 | |
| SCHEMBL14194670 | 0.83 | CDK2 (0.54) | CDK2CDK5CCNE1CDK9CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406263-A1 | PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | Centre National de la Recherche Scientifique (C.N.R.S.) (FR) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103486-A1 | PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-09-16 | — | — | WO | disclosed |