Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.66 |
| ▸ | JAK2 | O60674 | 4/20 | 0.64 |
| ▸ | JAK1 | P23458 | 4/20 | 0.64 |
| ▸ | TTK | P33981 | 2/20 | 0.64 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18506716 | 0.88 | JAK3 (0.52) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL28887510 | 0.86 | JAK3 (0.58) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL17209791 | 0.84 | JAK3 (0.76) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL14812608 | 0.81 | JAK3 (0.78) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL23152743 | 0.81 | EGFR (0.70) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL14812381 | 0.81 | JAK3 (0.77) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL17209782 | 0.78 | JAK3 (1.00) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL28887608 | 0.78 | JAK3 (0.59) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL23152840 | 0.78 | EGFR (0.63) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL17209783 | 0.77 | JAK3 (1.00) | JAK3JAK2JAK1TTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017477-B2 | Janus kinase inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170044111-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-02-16 | — | — | US | disclosed |
| WO-2015164614-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044111-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | JAK3, JAK1, JAK2 | JAK3 1/4885JAK2 3/4885JAK1 2/4885 |
| US-10017477-B2 | Janus kinase inhibitors and uses thereof | JAK3, JAK1, JAK2 | JAK3 1/4885JAK2 3/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.