⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4892282 | 0.83 | — | — | |
| SCHEMBL8806185 | 0.69 | — | — | |
| SCHEMBL29636819 | 0.67 | — | — | |
| SCHEMBL9118567 | 0.64 | — | — | |
| SCHEMBL9034589 | 0.64 | — | — | |
| SCHEMBL7797825 | 0.64 | — | — | |
| SCHEMBL2724026 | 0.62 | — | — | |
| Bromide SCHEMBL10911861 | 0.61 | — | — | |
| SCHEMBL8663400 | 0.57 | KDM1A (0.34) | — | |
| SCHEMBL9966918 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729274-B2 | Tricyclic heterocyclic derivatives | MERCK SHARP & DOHME B.V. (NL) | 2014-05-20 | — | — | US | disclosed |
| US-20120232122-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-09-13 | — | — | US | disclosed |
| EP-2406217-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | MSD Oss B.V. (NL) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103001-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2010-09-16 | — | — | WO | disclosed |
| EP-0805812-B1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-0808318-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | Abbott Laboratories (US) | 1997-11-26 | — | — | EP | disclosed |
| EP-0805812-A1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | Abbott Laboratories (US) | 1997-11-12 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022991-A1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |
| EP-0539209-A1 | Benzo-isoquinoline derivatives and analogs and their use in therapeutics | THE UPJOHN COMPANY (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5180733-A | Antidepressants or nervous systen disorders | ABBOTT LABORATORIES (US) | 1993-01-19 | — | — | US | disclosed |
| WO-1992021654-A2 | CARBOXAMIDO-(3,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-12-10 | — | — | WO | disclosed |
| WO-1992020655-A1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0482084-A1 | (1,2N) AND (3,2N)-CARBOCYCLIC-2-AMINO TETRALIN DERIVATIVES. | UPJOHN CO (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0461353-A1 | Biogenic amine uptake inhibitors | ABBOTT LABORATORIES (US) | 1991-12-18 | — | — | EP | disclosed |
| WO-1991000856-A2 | (1,2N) AND (3,2N)-CARBOCYCLIC-2-AMINO TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-24 | — | — | WO | disclosed |
| EP-0095666-B1 | TETRAHYDRO-BENZO(E) ISOINDOLINES | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |
| US-4618683-A | Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives | ABBOTT LABORATORIES (US) | 1986-10-21 | — | — | US | disclosed |
| US-4618683-A | Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives | ABBOTT LABORATORIES (US) | 1986-10-21 | — | — | US | disclosed |