Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16266021 | 0.92 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL413950 | 0.92 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL442763 | 0.92 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL442175 | 0.91 | MTOR (0.62) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL413960 | 0.91 | MTOR (0.62) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL443656 | 0.91 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL443657 | 0.91 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL16109384 | 0.90 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL16109386 | 0.90 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL16266037 | 0.88 | MTOR (0.59) | MTORPIK3CACYP3A4KCNH2RPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406258-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | Cellzome Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103094-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | CELLZOME LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |