Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654677 | 0.92 | PI4KB (0.64) | PI4KBKCNH2CYP3A4ADORA2AADORA3 | |
| SCHEMBL654372 | 0.89 | PI4KB (0.64) | PI4KBKCNH2CYP3A4CHIAPPARG | |
| SCHEMBL653167 | 0.89 | PI4KB (0.75) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL656541 | 0.85 | PI4KB (0.81) | PI4KBKCNH2CYP3A4CHIAPOLB | |
| SCHEMBL655537 | 0.85 | PI4KB (0.68) | PI4KBKCNH2CYP3A4CHIALMNA | |
| SCHEMBL1720392 | 0.84 | PI4KB (0.58) | PI4KBKCNH2CYP3A4CHIAPPARG | |
| SCHEMBL654457 | 0.82 | PI4KB (0.77) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL652821 | 0.82 | PI4KB (0.64) | PI4KBKCNH2CYP3A4LMNAMAPK1 | |
| SCHEMBL654471 | 0.82 | PI4KB (0.75) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL652412 | 0.82 | PI4KB (0.65) | PI4KBKCNH2CYP3A4POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |