Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 8/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17213122 | 0.91 | KDM4E (0.33) | GRK6TYMPCYP2C19ALDH1A1 | |
| SCHEMBL18552252 | 0.87 | GRK6 (0.37) | GRK6TYMPALDH1A1SMN1; SMN2 | |
| SCHEMBL17213094 | 0.83 | GRK6 (0.37) | GRK6TYMPCYP2C19MAPTALDH1A1 | |
| SCHEMBL21763927 | 0.82 | GRK6 (0.33) | GRK6CYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL17213092 | 0.82 | GRK6 (0.44) | GRK6TYMPMAPTPLA2G1BATG4B | |
| SCHEMBL17213052 | 0.81 | CHEK1 (0.39) | GRK6TYMPCYP2C19MAPTPLA2G1B | |
| SCHEMBL17213118 | 0.81 | TYMP (0.44) | GRK6TYMPMAPTPLA2G1BATG4B | |
| SCHEMBL17212979 | 0.81 | TYMP (0.40) | GRK6TYMPCYP2C19MAPTPLA2G1B | |
| SCHEMBL17213032 | 0.80 | GRK6 (0.44) | GRK6TYMPMAPTPLA2G1BATG4B | |
| SCHEMBL17213154 | 0.80 | GRK6 (0.39) | GRK6TYMPCYP2C19MAPTPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015164415-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-10-29 | — | — | WO | disclosed |