Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721676 | 0.85 | CFTR (0.55) | CFTRHDAC1 | |
| SCHEMBL12189143 | 0.83 | CFTR (0.53) | CFTR | |
| SCHEMBL12189211 | 0.83 | CFTR (0.60) | CFTR | |
| SCHEMBL4116058 | 0.83 | CFTR (0.63) | CFTR | |
| SCHEMBL29574769 | 0.83 | NPC1 (0.63) | CFTRHDAC1 | |
| SCHEMBL1684357 | 0.83 | NPC1 (0.63) | CFTRHDAC1 | |
| SCHEMBL1014497 | 0.83 | CFTR (0.55) | CFTRHDAC1 | |
| SCHEMBL1721299 | 0.83 | NPC1 (0.64) | CFTRHDAC1 | |
| SCHEMBL1723478 | 0.83 | CFTR (0.57) | CFTRHDAC1 | |
| SCHEMBL12231249 | 0.82 | CFTR (0.62) | CFTRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3696174-A1 | HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2020-08-19 | — | — | EP | disclosed |
| EP-3208272-A1 | HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-08-23 | — | — | EP | disclosed |
| EP-2774925-B1 | Heterocyclic modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2016-12-28 | — | — | EP | disclosed |
| EP-2774925-A1 | Pharmaceutical composition containing a heterocyclic modulator of ATP-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2014-09-10 | — | — | EP | disclosed |
| EP-2395002-B1 | PHARMACEUTICAL COMPOSITION CONTAINING A HETEROCYCLIC MODULATOR OF ATP-BINDING CASSETTE TRANSPORTERS. | VERTEX PHARMA (US) | 2014-06-18 | — | — | EP | disclosed |
| EP-1945632-B1 | HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2013-09-18 | — | — | EP | disclosed |
| EP-2404919-B1 | Heterocyclic compound useful as a modulator of ATP-binding cassette transporters. | VERTEX PHARMA (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-2404919-A1 | Pharmaceutical composition containing a heterocyclic modulator of ATP-binding cassette transporters. | Vertex Pharmaceuticals Incorporated (US) | 2012-01-11 | — | — | EP | disclosed |
| EP-2395002-A1 | Pharmaceutical composition containing a heterocyclic modulator of ATP-binding cassette transporters. | Vertex Pharmaceuticals Incorporated (US) | 2011-12-14 | — | — | EP | disclosed |
| CN-101356170-A | Heterocyclic modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2009-01-28 | — | — | CN | disclosed |