Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | STK16 | O75716 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13579644 | 0.90 | AURKA (0.49) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220344 | 0.89 | KDR (0.45) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220129 | 0.86 | KDR (0.42) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220157 | 0.86 | AURKA (0.46) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220420 | 0.85 | AURKA (0.42) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220243 | 0.84 | JAK2 (0.41) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220303 | 0.84 | KDR (0.40) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220085 | 0.84 | AURKA (0.40) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17219987 | 0.82 | AURKA (0.41) | AURKAJAK2JAK1KDRTYK2 | |
| Trifluoroacetic Acid SCHEMBL17220317 | 0.82 | AURKA (0.39) | AURKAJAK2JAK1KDRTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299821-B1 | TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2015-11-04 | — | — | EP | disclosed |